プロリルイソメラーゼPin1はアセチルCoAカルボキシラーゼ1タンパク質に結合して安定化させる。結果として癌細胞増殖を支持する。

広島大学(Hiroshima University)博士(医学)Doctor of Philosophy in Medical Sciencedoctora

Numerical analysis of the eutectic melting and relocation of the b4c control rod materials by the MPFI-MPS method

Eutectic melting and subsequent relocation of the boron-carbide (B4C) control rod materials were simulated by a particle method. In the past, it was difficult to simulate the eutectic melting by a particle method because the melting starts at the interface between two different materials, which leads to the instability of the particle motion due to the small amount of fluid particles and lack of the thermodynamic consistency of the particle system. Thus, the Moving Particle Full Implicit (MPFI)-Moving Particle Semi-implicit (MPS) method was developed and introduced in the current study. Specifically, the MPFI method was introduced for the momentum transfer calculation, and the MPS method was introduced for the heat and mass transfer calculation. The MPFIMPS method realized the simulation of the eutectic melting and subsequent relocation behaviour